Applies to: Docklight (all versions), Article ID: dl_faq047
Turns out you can, since such devices are not reserved for exclusive access by Windows like keyboards or mice.
See the download link below for an example project that works with a Logitec Rumblepad 2 game controller using USB HID.
Docklight Applications – Example project for Logitec Rumblepad 2 game controller
Docklight FAQ – Testing Bluetooth or USB HID devices